[Viral copies drop massively eight days after symptoms start[(https://news.northwestern.edu/stories/2023/09/covid-patients-exhale-up-to-1000-copies-of-virus-per-minute-during-first-eight-days-of-symptoms/)
Detailed viral kinetics show that some individuals still shed culturable virus at 12 days post-inoculation (i.e. up to 10 days after symptom onset) and, on average, viable virus was still detectable 10 days post-inoculation (up to 8 days after symptom onset). These data therefore support the isolation periods of 10 days post-symptom onset advocated in many guidelines to minimise onward transmission
LFA was highly reliable in predicting the disappearance of viable virus and therefore also underpin “test to release” strategies
there were no false positives when comparing LFA to qPCR, implying the relatively lower sensitivity of viral culture rather than false positivity of LFA
From my notes: first lateral flow detection (RAT) was 4 days. last detection 1-3 days after viable virus stopped, so good for "test to release"
So the old guidelines of "10 days from symptoms, or two negative RATs 48 hours apart" still seem valid to me.
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timeasmymeasure
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Date: 2024-08-12 05:00 am (UTC)[Viral copies drop massively eight days after symptoms start[(https://news.northwestern.edu/stories/2023/09/covid-patients-exhale-up-to-1000-copies-of-virus-per-minute-during-first-eight-days-of-symptoms/)
The small but controlled challenge trial
From my notes: first lateral flow detection (RAT) was 4 days. last detection 1-3 days after viable virus stopped, so good for "test to release"
So the old guidelines of "10 days from symptoms, or two negative RATs 48 hours apart" still seem valid to me.